Over the past two decades, one of the research topics in which many works have been done is spatial modeling of biomass through synergies between remote sensing, forestry, and ecology. In order to identify satellite-derived indices that have correlation with forest structural parameters that are related with carbon storage inventories and forest monitoring, topics that are useful as environmental tools of public policies to focus areas with high environmental value. In this chapter, we present a review of different models of spatial distribution of biomass and resources based on remote sensing that are widely used. We present a case study that explores the capability of canopy fraction cover and digital canopy height model (DCHM) for modeling the spatial distribution of the aboveground biomass of two forests, dominated by Abies Religiosa and Pinus spp., located in Central Mexico. It also presents a comparison of different spatial models and products, in order to know the methods that achieved the highest accuracy through root-mean-square error. Lastly, this chapter provides concluding remarks on the case study and its perspectives in remote sensing-based biomass estimation.